Wirkstoffdesign

This unique textbook for the German-speaking region is aimed at students of pharmacy, chemistry, and life sciences, as well as newcomers to research and development departments in the pharmaceutical industry. The second edition has been completely revised. Numerous current developments, particularly in the methodological area, are addressed in new chapters. Many case studies illustrate the theories and procedures in a clear and understandable way. The content spans from the history of drug research, the mechanisms of action of active substances, and methods for lead structure search and optimization, to structure determination methods, modeling, molecular dynamics, and QSAR methods, culminating in structure- and computer-aided design. Overall, the book places special emphasis on the spatial structure of interacting molecules and explains why a particular active substance is practically determined by the geometry and mechanism of action of the target protein. The accompanying DVD with interactive molecular models aims to provide learners with easy access to the spatial understanding of molecular structures and interactions.