Leber und die Mechanismen der Gallebildung

The work focuses on modern concepts of the physiological and molecular biochemical mechanisms of bile formation and secretion. Significant advances in understanding these mechanisms have been achieved due to fundamental progress in cell and molecular biology, genetics, and biochemistry over the past 50 years. To understand the processes of bile formation, it is important to know the macro and microstructure of the liver, the bile ducts, and their normal function. For this reason, the monograph begins with an examination of the structure and function of the liver and its blood supply, the characteristics of functional hepatocyte polarity, the structure of bile capillaries, ducts, and the gallbladder. The composition of bile, biosynthesis and conjugation of bile acids, bile phospholipids, formation of bile micelle structures, and the enterohepatic circulation of bile acids, as well as the molecular physiology of the transport systems of hepatocyte membranes, are described. Understanding the physiological foundations of bile formation has implications for understanding the mechanisms of the development of pathological processes associated with liver and bile duct diseases.