Toxizität von Iscador QuFrF

As a result of the HIV infection, according to the anthroposophical worldview, the four components of human nature become uncoupled due to a changed rhythm, and the immune system is weakened in its defensive function. In the context of this prospective, open-label, multicenter Phase II/III study, the immunomodulatory efficacy and toxicity of a mistletoe extract VaQuFrF were examined in HIV-positive patients over 48 weeks. A total of 1,827 adverse events (AEs) were recorded among 103 patients in the study, with all reported AEs being of mild (94%) to moderate (6%) severity. The AEs with a confirmed causal relationship to VaQuFrF were almost exclusively the local reaction independent of the Iscador concentration following the Iscador QuFrF injection. In the dose-escalation phase, primarily fatigue, flu-like symptoms, fever over 38°C, and headaches were reported, reflecting the response to therapy with Iscador QuFrF. No difference was found in the immunological effects between the adjuvant therapy of Iscador QuFrF combined with ART and the monotherapy with Iscador QuFrF.