The Male Role in Pregnancy Loss and Embryo Implantation Failure

The book "The Male Role in Pregnancy Loss and Embryo Implantation Failure" offers a comprehensive examination of the man's role in pregnancy losses and the failure of embryo implantation. It highlights the latest research findings that go beyond the traditional view that the man merely contributes an abnormal chromosome set at fertilization. Instead, it discusses how chromosomal microdeletions and duplications, epigenetic dysregulation through sperm microRNAs, and DNA damage caused by reactive oxygen species or environmental toxins can play a role in these processes. Furthermore, the complex composition of seminal plasma is considered, which contains crucial factors that influence the uterine environment and the woman's immune system to facilitate successful embryo implantation and the growth of the trophectoderm. This interdisciplinary perspective opens new avenues for clinical application and future translational research.