RecQ Helicase

The book "RecQ Helicase" provides a comprehensive analysis of the RecQ helicase, an important enzyme from the helicase superfamily 2. It discusses the structure and function of the various conserved domains, including the catalytic core and the HRDC domain. Through homology modeling, an attempt was made to reconstruct the structure of the E. coli RecQ protein, and molecular dynamics simulations were conducted to investigate the interaction between the protein and DNA. The results show that the structure of the RecQ protein is stable and exhibits interesting dynamic properties, indicating an inherent flexibility of the protein. This flexibility could play a crucial role in binding to DNA and the catalytic activity of the enzyme. The book is aimed at professionals and students engaged in molecular biology and biochemistry who wish to gain a deeper understanding of the mechanisms of DNA helicase.