Novel mechanisms in the response of tumour cells to iron depletion

The book "Novel mechanisms in the response of tumour cells to iron depletion" offers a comprehensive analysis of the role of iron deficiency in tumor biology. It highlights the critical processes influenced by iron, particularly DNA synthesis and the cell cycle. The author, Federica Saletta, presents compelling data showing that iron chelators exhibit high efficacy in inhibiting tumor growth by targeting multiple molecular pathways. The investigation of the regulatory elements responsible for the iron deficiency-mediated regulation of DNA repair genes, as well as the identification of the specific transcription factor NF-YA, are central themes of the book. Furthermore, the ability of iron deficiency to regulate gene translation and the modulation of genes associated with metastasis are discussed. These findings are crucial for understanding the selective anti-proliferative effects of chelators on neoplastic cells and the underlying mechanisms of cell cycle arrest, DNA damage repair, and apoptosis.