Modello preclinico di leucemia promielocitica umana in topi NSG

The book "Preclinical Model of Human Promyelocytic Leukemia in NSG Mice" by Giovanna Talarico offers a comprehensive investigation into the development of a human model for acute promyelocytic leukemia (APL) using NSG mice. APL is a complex disease characterized by the specific genetic translocation t(15;17), which leads to the formation of the PML/RARalpha fusion protein. In recent years, it has become evident that much of the knowledge about the molecular mechanisms of APL is based on cell lines that do not always reflect the actual tumor conditions. This work highlights the significant advancements made through the use of NSG mice, which allow for the successful engraftment of human APL cells in the blood, bone marrow, and spleen of the mice. The results of this research could have far-reaching implications for future studies in the field of leukemic stem cells and leukemia biology by providing an easily accessible in-vivo model for APL that supports the development of specific therapeutic approaches for patients.