Leptin

The book "Leptin" by Sam Dagogo-Jack offers a comprehensive analysis of the hormone leptin, which was discovered twenty years ago and is now approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. It begins with a synthesis of the extensive research on its discovery, mechanisms, and effects in experimental models. The focus is on the regulation and role of leptin in the human body, with an emphasis on human-level data being a distinctive feature of this work. The results of numerous studies demonstrate that leptin is a regulated human hormone. The book provides a detailed account of the diverse physiological, hormonal, metabolic, immunological, mitogenic, and inflammatory modulators and target structures of leptin in a single volume. Additionally, it offers a comprehensive presentation of therapeutic studies on recombinant leptin in patients with congenital leptin deficiency and lipodystrophy.