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Springer

The book "Group Sequential and Confirmatory Adaptive Designs in Clinical Trials" provides a comprehensive and up-to-date overview of the general principles and techniques of confirmatory adaptive designs in clinical trials. These designs represent an extension of group sequential designs and allow for interim analyses to be conducted, enabling the early termination of the study while ensuring control over the Type I error rate. Furthermore, the adaptive methodology permits data-driven changes to relevant aspects of the study design during interim phases, such as reassessing the sample size or selecting treatment arms. The book is aimed at applied statisticians from academia and industry who are interested in the methodology and planning of adaptive designs. It covers the methodology at a fundamental level and offers numerous examples for practical application.

Actual product image Group Sequential and Confirmatory Adaptive Designs in Clinical Trials (English, Paperback, Gernot Wassmer, Werner Brannath)

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