DNA Relaxases, the Key Enzymes of Bacterial Conjugation

"DNA Relaxases, the Key Enzymes of Bacterial Conjugation" is a specialized book that focuses on the role of relaxases in bacterial conjugation. These enzymes are crucial for horizontal gene transfer, particularly for the transfer of plasmid DNA between bacterial cells. The book highlights the mechanisms through which bacteria acquire antibiotic resistance and describes the specific process of conjugation, where DNA is transferred from a donor cell to a recipient cell. The author, Jolanta Kopec, specifically examines the DNA relaxase TraA, which is encoded by the Gram-positive plasmid pIP501. Through various experimental techniques, such as small-angle X-ray scattering and chemical cross-linking, the structure and function of these enzymes are analyzed in detail. The book provides valuable insights into the biochemical processes that lead to antibiotic resistance and is an important resource for professionals and students in the fields of microbiology and biochemistry.