Design and Synthesis of Some New AChEIs as Anti-Alzheimer Agents

The textbook "Design and Synthesis of Some New AChEIs as Anti-Alzheimer Agents" offers a comprehensive investigation into the synthesis of new isoindolin-1,3-dione derivatives developed as potential anti-Alzheimer agents. The authors, Uttam A. More and Malleshappa N. Noolvi, present detailed experimental methods, including the use of TLC to monitor reactions and the characterization of compounds through IR, 1H NMR, 13C NMR, and mass spectrometry. A key component of the research was the in silico study, which examined the interactions of the new molecules with the acetylcholinesterase enzyme. The results of the docking studies and in vitro tests, particularly the promising activity of compound 7a with an IC50 of 32 nM, are discussed in detail. This book is aimed at professionals and students in the fields of medicine and nursing who are interested in developing new therapeutic approaches to combat Alzheimer’s disease.