Control and Prediction of Solid-State of Pharmaceuticals

The textbook "Control and Prediction of Solid-State of Pharmaceuticals" by Rajni Miglani Bhardwaj offers a comprehensive examination of experimental and computational approaches to the discovery of solid forms of pharmaceutical compounds. It provides readers with an in-depth understanding of the key factors that influence solid-state structure and its diversity. A significant portion of the work focuses on experimental investigations of two structurally similar compounds. Additionally, the impact of small structural changes and substituents on the solid-state structure is analyzed using computational tools such as crystal structure prediction and statistical modeling techniques. The author also presents a rapid, validated method for screening solid forms that utilizes Raman microscopy on multiwell plates to explore the experimental crystallization space. This work offers a cost-effective, practical, and precise way to predict the crystallization potential of organic compounds based on their molecular structure.