Blutgeschwindigkeit, Die Zur Flussvermittelten Dilatation Beiträgt

Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in Western countries. Endothelial dysfunction precedes atherosclerosis and subsequent CVD. This dysfunction can be monitored by assessing a phenomenon known as flow-mediated dilation (FMD) – the regulation of vessel diameter in response to changes in shear rate. A popular non-invasive test for FMD has been developed, recognized for its ability to predict CVD. However, this test would be more sensitive and reliable if the FMD response to the shear stimulus were normalized. This book includes a literature review on the relationship between blood velocity/shear rate and FMD, as well as results from two studies. The purpose of the first study was to determine the significance of velocity acceleration for FMD. The second study investigated whether peak and time-integrated shear rates independently predict FMD. Taken together, these studies suggest: 1) Shear stimuli are not a linear function of mean blood velocity. And 2) Peak and time-integrated shear rates independently predict FMD.