A New Approach to Cancer Risk Assessment: An Overview

"A New Approach to Cancer Risk Assessment: An Overview" offers a comprehensive analysis of methods for assessing cancer risk, particularly concerning agrochemical substances and other potential carcinogens. In light of the challenges posed by climate change, which promotes the growth of certain insects, molds, and invasive plant species, the need for reliable assessment methods is becoming increasingly urgent. The book highlights the complex processes of experimental carcinogenesis, ranging from initiation to promotion and malignant progression. It demonstrates how faulty DNA repair mechanisms and the subsequent clonal expansion of damaged cells play a central role. Additionally, it explores the connection between cancer development and the improper regulation of programmed cell death, as well as the resulting dysregulation of cell proliferation. This new perspective on cancer risk assessment takes into account both genetic and epigenetic factors that influence the apoptotic mechanisms underlying carcinogenesis.