Question about Logitech Harmony Ultimate One

Difficult to say, because everyone would have a different set of devices to connect. I think it should be no problem and it should work well for your needs. I have connected Samsung DVD, Samsung BluRay / Media player, Onkyo AV receiver, Epson beamer, Samsung TV - all works with the sigle remote without any problem and you don't need your deviced to be "smart" (e.g. my beamer isn't) nor to be connected to the internet. You configure all devices in your profile on the web page of logitec.
You can further check about compatibility of your devices on the logitec web page. Good luck!